I think this quote is the best answer I can find:
Consider the feature common to all of the above: we have chosen comfort and short-term convenience over the option presented to us by our genome and the Pleistocene environment in which our genome (and so our phenotype) evolved.
These more comfortable, pleasurable and convenient options have been laid before us by the abundance of cheap energy, which has also underwritten the complexity of our society. As a species, we are so easily seduced by – for example – cheap takeaway pizza in front of the television in a centrally heated house, that we are unlikely to chose to grow our own food (planting months in advance), gather and cut our own firewood (again, months in advance of its intended use) and prepare and cook our own meal and wash up afterwards.
Our choices appear to be “no-brainers”, but consider the avoidance of physical activity, the avoidance of disciplined planning and sustained execution, our brushing aside the environmental consequences of our choices and our avoidance of engagement with the natural world. What a price!
At the heart of it is a cheap and very useful source of energy – oil.
And when Oil is neither cheap or easy we will have to get real again.
The choice is do we keep our eyes and shut and do nothing or do we build the Ark? For our health and wellbeing depend on our having the best fit.
The principle that if an animal or plant is removed from its natural habitat, or if the environment changes in some significant way, it is likely that it will be less well adapted to the new conditions, and will consequently show some signs of physiological or behavioural maladjustment. This principle applies to all species including Homo sapiens. 
Stephen Boyden goes on to say that:
Humans today are biologically the same animal as their ancestors who lived long before the advent of farming – that is, an animal genetically adapted through natural selection to the life of hunter-gatherers. This fact has important implications for our understanding of ourselves and the challenges that face us in the modern world.