Category Archives: Aging

The Exercise Myth – Strength and Activity

From Chris Highcock’s wonderful short PDF book which you can buy here. Chris’s book opens with the best context for Fitness and its link to health and how we grow old that I have yet seen. This site has talked … Continue reading

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Brilliant new interview with Michael Rose on Aging and Health

Please follow the link here.

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Michael Rose’s New Scientist Article – Aging can stop

Aging isn’t cumulative process of progressive chemical damage — it can stop By Michael R. Rose, Published: September 6 In 1939, British statisticians Major Greenwood and J.O. Irwin published a little-noticed article in the journal Human Biology that contained a profoundly unexpected … Continue reading

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So when will you lose your health – Part 5 – What to do

As we all worry about the current fiscal situation – this is the time bomb. As so many of us age AND as so many of us who are not that old, get sick from the diseases of Modern Civilization, … Continue reading

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So when will you lose your health – Part 2 – When you live in the wrong environment

You get ill when you look like this – this is how I looked aged 59 – I weighed 205 lbs. How I look here has all the signs that you have not lived your life according to the rules. … Continue reading

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Michael Rose – Saved my life

Here I am in August 2009 – pre diabetic – a typical middle aged man. I thought that this was my destiny – that all men of my age had to be like this. But after talking with Michael Rose … Continue reading

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Why did we stray so far from our Evolutionary Best Fit?

I think this quote is the best answer I can find:  Consider the feature common to all of the above: we have chosen comfort and short-term convenience over the option presented to us by our genome and the Pleistocene environment … Continue reading

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Why are we so fat in rural settings? – Part 3 – Our Ancestry!

Prince Edward Island, where I live, has a very high obesity rate. So do many rural parts of America and of cource the rest of Atlantic Canada. We have looked at why there is an physical environmental difference between cities and … Continue reading

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How do you get control and power – Riot or take it for yourself?

Lack of power and control and low social status is a major factor in making us ill. So if we cannot change the system, how can we get more power, control and social status? This week we will look at how we might do … Continue reading

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Are you at risk of getting ill? Yes when we get older

My son who is 31 likes what he sees in how I have changed but is having trouble with giving up modern foods for himself. Especially beer! I told him that, as a Scot – he is a Celt and … Continue reading

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Aging – What is it and why you can avoid it’s ravages

What is aging? Is the deterioration we see inevitable? Are the diseases that come with age all part of the process? Is it inevitable that we get sick and decrepit as we get older? On the surface it looks as … Continue reading

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Michael’s Recent Interview

Michael is interviewed by Jimmie Moore on how Evolution plays such a role and also on how diet is so important. Here MR summarizes the key factors of the 55 in a few minutes.  

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As primates we need to live in the “right” social environment – much of our illness stems from a poor fit – the cure is a better fit.

A central tenet of Michael’s is that we do best in environments that fit our evolved state. Diet is a very important aspect of finding the best fit. But so is our social environment. Practical work at one of Canada’s … Continue reading

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The “Plateau” – Thesis #30 in action

Here is a short video of Ruth – soon to be 100. My real point of posting her video is to remind us all that there is a plateau waiting for us as we get older. If we are not … Continue reading

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Sir Michael Marmot to expand the Whitehall Study to look at why we “age” differently

Marmot’s Whitehall Study is a longitudinal study that has studied the effects of social status on health. He used as his sample a large number of well educated British Civil Servants – Hence “Whitehall”. A key finding has been the … Continue reading

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Thesis 26

Thesis #26 – The forces of natural selection can be strengthened during adulthood by postponing the first age at which they begin to decline, which can be achieved for the force of natural selection acting on age-specific mortality by postponing … Continue reading

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Thesis 27

Thesis #27 – Among populations which have had their forces of natural selection strengthened experimentally, detectable improvements in adult survival and reproduction have been observably achieved within dozens of generations. So there I am, in 1977, realizing that all evolution … Continue reading

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Thesis 28

Thesis #28 – Among such experimental populations evolving greater levels of adaptation at later adult ages, evolutionary changes in (a) structural gene frequency, (b) gene regulation, (c) patterns of cumulative damage, and (d) still other features of physiological function will … Continue reading

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Thesis 29

Thesis #29 – Species with fully symmetrical fission as the sole means of reproduction do not have a declining force of natural selection acting on survival, and they do not evolve aging phases in which all individuals show declining survival. … Continue reading

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Thesis 30

Thesis #30 – The forces of natural selection plateau at zero values at very late adult ages, and do not decline further for all subsequent ages. This is the most important thing of all, even if no one understood what … Continue reading

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Thesis 31

Thesis #31 – After the forces of natural selection plateau, it is possible for survival and reproduction to plateau at positive values due to age-independent beneficial effects of some genetic variants. As with modern physics, again, it is often difficult … Continue reading

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Thesis 32

Thesis #32 – Before the forces of natural selection plateau, it is possible for genetic drift, due to small population sizes among other possibilities, to weaken the ability of natural selection to distinguish among genetic variants affecting later adult life, … Continue reading

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Thesis 33

Thesis #33 – When late-adult plateaus in survival and reproduction occur, members of biological cohorts that reach such plateaus will show stabilization of some but not necessarily all functional characters. Evolutionary theory makes a simple prediction about how the key … Continue reading

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Thesis 34

Thesis #35 – Severe antagonistic pleiotropy can cause the evolution of zero late-adult survival probability even under ideal conditions, when genetic trade-offs between early reproduction and subsequent adult survival are sufficiently strong. Not all organisms have three phases to their … Continue reading

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Thesis 35

Thesis #35 – The ages at which the forces of natural selection plateau depend on the last ages of reproduction and survival in the evolutionary history of a population, allowing experimental evolution of the cessation of aging by deliberately changing … Continue reading

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Thesis 36

Thesis #36 – Experimental populations which have evolved different time-points for the cessation of aging can be used to uncover the biological foundations that determine the timing of the cessation of aging. During the 1980s and 1990s, my laboratory devoted … Continue reading

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Thesis 37

Thesis #37 – Patterns of aging, including the rates of decline of functional characters and the timing of any cessation in such decline, depend on the environments in which cohorts are raised and live as adults. (Picture of Einstein talking … Continue reading

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Thesis 38

Thesis #38 – Some environmentally-induced variation in patterns of aging reflects the impact of selectively-favored patterns of life-history plasticity, but some environmental variation in aging does not reflect adaptive plasticity, such as that due to novel environments. An important distinction … Continue reading

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Thesis 39

Thesis #39 –  Patterns of adaptation are jointly determined by long-antecedent evolutionary patterns of natural selection, mutation, and inbreeding, as well as the immediate impact of environmental manipulation. In studying the aging phase and other patterns of adaptation in an … Continue reading

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Thesis 40

Thesis #40 – Experimental strategies for the study of aging that involve the introduction of novel mutations or increased levels of inbreeding will systematically impair the scientific study of aging, as they degrade and disrupt adaptation generally. At this point, … Continue reading

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