Category Archives: Theses

“Cancering” – It’s all about systems not one thing

An exceptional piece that sheds light on the systemic issues related to Cancer. As Michael points out in the 55 is the flaw in how we approach science – reductionism – this video shows how different medicine will be. Dr … Continue reading

Posted in A New Vision, Context, Environments, Physiology, Resources, The New Science, The Science, Theses | Tagged , , | 1 Comment

Rose offers the scientific context/framework for Ancestral Health

Science is a mess today as is medicine. Every day we hear a new this or that. Many hold very strong beliefs based on what? What was missing was a context for health. This is what Michael has offered us. … Continue reading

Posted in "Paleo", A New Vision, Ancestry, Context, Diet, Forces of Natural Selection, The New Science, Theses | Tagged | 1 Comment

Michael Rose’s New Scientist Article – Aging can stop

Aging isn’t cumulative process of progressive chemical damage — it can stop By Michael R. Rose, Published: September 6 In 1939, British statisticians Major Greenwood and J.O. Irwin published a little-noticed article in the journal Human Biology that contained a profoundly unexpected … Continue reading

Posted in A New Vision, Aging, The New Science, The Science, Theses | Tagged , | 2 Comments

The Full Lindeberg!

“Food and Western Disease” by Staffan Lindeberg, MD, PhD from Ancestry on Vimeo. Here are his slides – here is the link to his website. AHS Slides_Staffan Lindeberg View more presentations from Ancestry

Posted in "Paleo", A New Vision, Ancestry, Complexity, Context, Environments, Population, The Science, Theses | Tagged

So when will you lose your health – Part 4 – How to get it back – Not from medicine

You are reading this post because you believe in a new understanding of how our health works. You know that you can take charge of your health. So why, if you know this to be true, is it so hard … Continue reading

Posted in "Paleo", A New Vision, Context, Resources, The New Science, The Science, Theses | Tagged , , , ,

Why are we so fat in rural settings? – Part 3 – Our Ancestry!

Prince Edward Island, where I live, has a very high obesity rate. So do many rural parts of America and of cource the rest of Atlantic Canada. We have looked at why there is an physical environmental difference between cities and … Continue reading

Posted in "Paleo", A New Vision, Aging, Ancestry, Constraints, Context, Diet, Environments, Evolutionary Novelty, Physiology, Plateau, Population, The Plateau, The Science, Theses | Tagged , , | 4 Comments

How do you get control and power – Riot or take it for yourself?

Lack of power and control and low social status is a major factor in making us ill. So if we cannot change the system, how can we get more power, control and social status? This week we will look at how we might do … Continue reading

Posted in "Paleo", A New Vision, Aging, Constraints, Diet, Environments, Evolutionary Novelty, Experimental Evolution, Population, Resources, The Science, Theses, Trade Offs | Tagged , ,

Your Baby – Bathtime – What is safe? – Novel Environments

My grand daughter Sophia when she was very little not so long ago. Bath time is the best part of the day for babies and parents. Little did I know what might have been going on. What is in the … Continue reading

Posted in Constraints, Environments, Evolutionary Novelty, Theses | Tagged ,

Diet – What you need to know based on your heritage

Thesis 50 reminds us that if you are a person with a heritage that is adapted to the agricultural diet – say from Western Europe – then you can do quite well on the Agricultural diet for a while. 30 … Continue reading

Posted in Ancestry, Diet, Environments, Plateau, Population, The Plateau, The Science, Theses | Tagged

Diet – Where your ancestral heritage is important

Surely we must have adapted to agriculture by now? The answer is no and sort of yes to that question. It depends on what your ancestral heritage is or how long you have been exposed to agriculture. Let’s take dairy. … Continue reading

Posted in Ancestry, Constraints, Context, Diet, Environments, Evolutionary Novelty, Forces of Natural Selection, Physiology, Population, The Science, Theses | 12 Comments

Aging – What is it and why you can avoid it’s ravages

What is aging? Is the deterioration we see inevitable? Are the diseases that come with age all part of the process? Is it inevitable that we get sick and decrepit as we get older? On the surface it looks as … Continue reading

Posted in A New Vision, Aging, Context, Plateau, The New Science, The Plateau, The Science, Theses | 2 Comments

Thesis #1

Thesis #1 The biological fitness of a population is the average net reproduction of its members, which in turn is determined by their capacity to survive and reproduce; biological fitness is at the core of health. The starting point of … Continue reading

Posted in Theses | Tagged , | 5 Comments

Thesis # 2

Thesis #2 – Natural selection reliably produces high levels of biological fitness, and thus good health, only under the environmental conditions in which it has been acting for many generations. A common caricature of evolution by natural selection is that … Continue reading

Posted in Constraints, Theses | Tagged , , | 1 Comment

Thesis # 3

Thesis #3. Health and adaptation thus reflect the action of natural selection on a population in its previous environments, not its present environment, when these differ. For the purpose of re-founding medicine scientifically, theses 2 and 3 direct us to … Continue reading

Posted in Constraints, Environments, Physiology, The Science, Theses | 2 Comments

Thesis #4

Thesis #4 Natural selection results in the evolution of good health only when there is sufficient heritable variation affecting survival and reproduction. Natural selection accomplishes nothing without an adequate and appropriate supply of genetic variation on which to act.  That … Continue reading

Posted in Constraints, Theses | Tagged

Thesis #5

Thesis #5  Natural selection produces good health only when population size is large enough to overcome genetic drift; inbreeding reliably impairs health in outbreeding species. Many members of the human species have a great propensity to mate with other humans.  … Continue reading

Posted in Theses | Tagged , ,

Thesis #6

Thesis #6 Natural selection produces good health only when new deleterious mutations are rare or small in magnitude; very few novel mutations will have large and generally beneficial effects, in an environment to which a population is well-adapted. Mutation is … Continue reading

Posted in Theses | Tagged , , | 1 Comment

Thesis #7

Thesis #7 Natural selection will sustain nucleotide sequences that foster biological fitness however numerous and however indirect their benefits, making the genetic foundations for the evolution of health genome-wide and complex. The kinds of experiments that most biologists favor involve … Continue reading

Posted in Theses | Tagged , ,

Thesis #8

Thesis #8 This complex genomic foundation for adaptation in turn produces a still more complex network of interacting molecules that sustain survival, health, fertility, and function. Arising from the genetic complexity of healthy function is a still more complex set … Continue reading

Posted in Theses | Tagged , ,

Thesis #9

Thesis #9 The forces of natural selection weaken with adult age in species that have distinguishable adults and no fissile reproduction. We now face the prospect of developing a 21st Century biology based on formal, mathematical, and computational tools.  It … Continue reading

Posted in Theses | Tagged , ,

Thesis #10

Thesis #10 When the forces of natural selection weaken with adult age, declining survival and fertility evolve in adulthood, and thus produce the decline in health which is commonly called ‘aging.’ In animals like mammals and insects, the Force of … Continue reading

Posted in Theses | Tagged , ,

Thesis 11

Thesis #11 – If the forces of natural selection are strengthened during later adulthood, improved later health will evolve if natural selection is not impeded by very small population sizes, environmental change, or an absence of heritable variation. There are … Continue reading

Posted in Theses | Tagged , , ,

Thesis 12

Thesis #12 – Aging is a pattern of declining or de-tuned adaptation that is correlated with adult age only because adult age is at first strongly correlated with declining forces of natural selection. We have all seen sunrise and sunset.  … Continue reading

Posted in Theses | Tagged , , , , | 2 Comments

Thesis 13

Thesis #13 – The declining forces of natural selection lead to an evolutionary failure to establish the genomic information required for tuning the complex networks of life well enough to provide a high level of health indefinitely; there is no … Continue reading

Posted in Ancestry, Population, Reproduction, Theses | Tagged , , ,

Thesis 14

Thesis # 14 – Aging hypotheses based solely on supposed universal imperfections of molecular, cell, or organismal physiology are wholly falsified by the existence of biological species that do not exhibit falling average rates of survival and reproduction among large cohorts … Continue reading

Posted in Constraints, Theses | Tagged , , , ,

Thesis 15

Thesis # 15 – Aging evolves because of the previously adduced evolutionary genetic limitations to the forces of natural selection, which are affected by physiology, but aging is nonetheless not a merely physiological process.  Do the last five theses imply that … Continue reading

Posted in Constraints, Theses | Tagged , , , | 4 Comments

Thesis 16

Thesis #16 – Among the most important physiological constraints on the action of natural selection are trade-offs between the biological functions underlying age-specific rates of survival and reproduction. One of the most important features of physiology that affects the evolution of … Continue reading

Posted in Constraints, Theses, Trade Offs

Thesis 17

Thesis #17 – When such trade-offs arise from antagonistic pleiotropic effects of genetic variants, they sometimes maintain genetic variation for functional characters, and thus selectable genetic variation for patterns of aging. There are two kinds of trade-off which are important to … Continue reading

Posted in Theses, Trade Offs | Tagged , , ,

Thesis 18

Thesis #18 – When such trade-offs can be physiologically tuned within the lives of individual organisms, natural selection may act to produce physiological machinery that provides plasticity which enhances average fitness. One of the basic features of natural selection is its … Continue reading

Posted in Theses, Trade Offs | Tagged , , ,

Thesis 19

Thesis #19 – Such adaptive life-history plasticity will sometimes produce detectable trade-offs between survival and reproduction in the range of environmental conditions that prevailed when natural selection established such life-history plasticity. It is a general, though not universal, rule that, if … Continue reading

Posted in Theses, Trade Offs | Tagged , , ,