Category Archives: A New Vision

Your mind and your health – Part 3 – How do we change deep rooted thoughts/habits?

So how do we change? Is it as simple as knowing what is true? Not for deep change. I can hear you even from here. “But I can’t change my habits” or “Just telling me to think differently is not enough” … Continue reading

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Your Mind and your Health – Part 2 – The Power of Neuroplasticity

This is the conventional picture of the brain – a thing with discrete compartments – a thinking machine. This idea of the brain – which is also how most of us “see” the body and so organize medicine is wrong. … Continue reading

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How do you get control and power – Riot or take it for yourself?

Lack of power and control and low social status is a major factor in making us ill. So if we cannot change the system, how can we get more power, control and social status? This week we will look at how we might do … Continue reading

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Aging – What is it and why you can avoid it’s ravages

What is aging? Is the deterioration we see inevitable? Are the diseases that come with age all part of the process? Is it inevitable that we get sick and decrepit as we get older? On the surface it looks as … Continue reading

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Where can we find answers to the questions raised by Michael Rose? A Hack Community

Finding out how best to live in a way more attuned to our Paleo past is not a well established protocol yet. How do we give up sugar if we are addicted? What is the best form of activity to … Continue reading

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The PaleoGraphic – The Story in Pictures

Learn more about the Paleo Diet. From Paleolithicdiet.com

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Michael’s Recent Interview

Michael is interviewed by Jimmie Moore on how Evolution plays such a role and also on how diet is so important. Here MR summarizes the key factors of the 55 in a few minutes.  

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The Scientific Challenge

Biology is in a state of transformation.  Much like the re-foundings of biology that took place after 1800, 1859, 1900 and 1952, the first decade of the 21st Century has seen a major upheaval in biology.  The four previous revolutionary episodes … Continue reading

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Thesis 26

Thesis #26 – The forces of natural selection can be strengthened during adulthood by postponing the first age at which they begin to decline, which can be achieved for the force of natural selection acting on age-specific mortality by postponing … Continue reading

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Thesis 27

Thesis #27 – Among populations which have had their forces of natural selection strengthened experimentally, detectable improvements in adult survival and reproduction have been observably achieved within dozens of generations. So there I am, in 1977, realizing that all evolution … Continue reading

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Thesis 28

Thesis #28 – Among such experimental populations evolving greater levels of adaptation at later adult ages, evolutionary changes in (a) structural gene frequency, (b) gene regulation, (c) patterns of cumulative damage, and (d) still other features of physiological function will … Continue reading

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Thesis 29

Thesis #29 – Species with fully symmetrical fission as the sole means of reproduction do not have a declining force of natural selection acting on survival, and they do not evolve aging phases in which all individuals show declining survival. … Continue reading

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Thesis 30

Thesis #30 – The forces of natural selection plateau at zero values at very late adult ages, and do not decline further for all subsequent ages. This is the most important thing of all, even if no one understood what … Continue reading

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Thesis 31

Thesis #31 – After the forces of natural selection plateau, it is possible for survival and reproduction to plateau at positive values due to age-independent beneficial effects of some genetic variants. As with modern physics, again, it is often difficult … Continue reading

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Thesis 32

Thesis #32 – Before the forces of natural selection plateau, it is possible for genetic drift, due to small population sizes among other possibilities, to weaken the ability of natural selection to distinguish among genetic variants affecting later adult life, … Continue reading

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Thesis 34

Thesis #35 – Severe antagonistic pleiotropy can cause the evolution of zero late-adult survival probability even under ideal conditions, when genetic trade-offs between early reproduction and subsequent adult survival are sufficiently strong. Not all organisms have three phases to their … Continue reading

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Thesis 35

Thesis #35 – The ages at which the forces of natural selection plateau depend on the last ages of reproduction and survival in the evolutionary history of a population, allowing experimental evolution of the cessation of aging by deliberately changing … Continue reading

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Thesis 36

Thesis #36 – Experimental populations which have evolved different time-points for the cessation of aging can be used to uncover the biological foundations that determine the timing of the cessation of aging. During the 1980s and 1990s, my laboratory devoted … Continue reading

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Thesis 37

Thesis #37 – Patterns of aging, including the rates of decline of functional characters and the timing of any cessation in such decline, depend on the environments in which cohorts are raised and live as adults. (Picture of Einstein talking … Continue reading

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Thesis 39

Thesis #39 –  Patterns of adaptation are jointly determined by long-antecedent evolutionary patterns of natural selection, mutation, and inbreeding, as well as the immediate impact of environmental manipulation. In studying the aging phase and other patterns of adaptation in an … Continue reading

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Thesis 40

Thesis #40 – Experimental strategies for the study of aging that involve the introduction of novel mutations or increased levels of inbreeding will systematically impair the scientific study of aging, as they degrade and disrupt adaptation generally. At this point, … Continue reading

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Thesis 41

Thesis #41 – Experimental strategies for the study of aging that involve the use of environments that are evolutionarily novel will systematically impair the scientific study of aging, as natural selection will not have previously fostered adaptation to such novel … Continue reading

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Thesis 42

Thesis #42 – As a pattern of age-dependent adaptation, aging and the post-aging period are best studied using the range of methods used to study adaptation by evolutionary biologists, such as the comparative method, experimental evolution, and genomics. By this … Continue reading

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Thesis 43

Thesis #43 – Experimental manipulation of the forces of natural selection is one of the most powerful methods of studying the biological foundations of aging, because it can direct experimental evolution to produce extensive genetic differentiation with respect to both … Continue reading

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Thesis 44

Thesis #44 – Most of our ancestral hominin populations of the last million years benefited from increased forces of natural selection at early adult ages under conditions of relatively abundant nutrition derived from hunting, gathering, and cooking and an increased … Continue reading

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Thesis 45

Thesis #45 – Our ancestral hunter-gatherer populations had generally low population densities, and thus low effective population sizes, which produced relatively early cessation of aging at relatively high function due to genetic drift. With very low population densities among our … Continue reading

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Thesis 46

Thesis #46 – In the last ten to twenty thousand years, some human populations adopted extensive agricultural cultivation of grass species and the use of milk from other mammals for nutrition, a novel environment which changed the action of natural … Continue reading

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Thesis 47

Thesis #47 – This novel agricultural lifestyle initially depressed adaptation and health, leading to intense natural selection for adaptations to the digestion of foods derived from grasses and milk, which has since produced adaptation to agricultural conditions at early ages. … Continue reading

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Thesis 48

Thesis #48 – Agricultural populations have also undergone substantial increases in population size compared to those of their ancestral hunter-gatherer populations, which increased the effectiveness of natural selection at later adult ages, resulting in the evolution of a delay in … Continue reading

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Thesis 49

Thesis #49 – In agricultural populations over the last ten thousand years, the longer-sustained effectiveness of natural selection has resulted in an age-dependent pattern of falling adaptation to agricultural conditions in which functional decline is sustained over a longer period … Continue reading

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