Category Archives: Context

Aging – What is it and why you can avoid it’s ravages

What is aging? Is the deterioration we see inevitable? Are the diseases that come with age all part of the process? Is it inevitable that we get sick and decrepit as we get older? On the surface it looks as … Continue reading

Posted in A New Vision, Aging, Context, Plateau, The New Science, The Plateau, The Science, Theses | 2 Comments

The PaleoGraphic – The Story in Pictures

Learn more about the Paleo Diet. From Paleolithicdiet.com

Posted in "Paleo", A New Vision, Context, Diet, Environments, Evolutionary Novelty, Physiology, The New Science, The Science | Tagged

Michael’s Recent Interview

Michael is interviewed by Jimmie Moore on how Evolution plays such a role and also on how diet is so important. Here MR summarizes the key factors of the 55 in a few minutes.  

Posted in "Paleo", A New Vision, Aging, Ancestry, Context, Diet, Environments, Evolutionary Novelty, Forces of Natural Selection, Physiology, Plateau, Population, The New Science, The Science | Tagged ,

Talking about Environments – What about your mouth?

Ideally our mouths should be on the alkaline side. Before the modern diet, they were. Before the modern diet there was next to no caries. Today we brush our teeth to give us a chance of beating caries. But what … Continue reading

Posted in "Paleo", Constraints, Context, Diet, Environments, Evolutionary Novelty, Physiology | Tagged

Michael’s Rose’s “Twin Sister?” – Dr Mary Vernon – The practical aspect of the 55 Theses

No one I have found so far explains how our metabolism works better than Dr Vernon – a GP who could not help any of her diabetic patients get well by following the “rules”. Who then became an expert in … Continue reading

Posted in Complexity, Context, Diet, Environments, Evolutionary Novelty, Physiology, The Science | Tagged

The most important social environment to get right – the family

Michael Rose is clear – the closer we can live in environments that we have evolved to thrive in, the better off we will be. No environment has more of an effect on our well being than our family. For … Continue reading

Posted in Context, Environments, Physiology | Tagged , , , , ,

We need the best fit to our ideal social status as well as to our ideal diet

America spends far more than any other nation in the world on healthcare and yet has the health outcomes of a nation like Cuba. What is going on? Why might this be? If you live in Louisiana you are much … Continue reading

Posted in Context, Environments, Evolutionary Novelty, Population | Tagged , ,

Sir Michael Marmot to expand the Whitehall Study to look at why we “age” differently

Marmot’s Whitehall Study is a longitudinal study that has studied the effects of social status on health. He used as his sample a large number of well educated British Civil Servants – Hence “Whitehall”. A key finding has been the … Continue reading

Posted in Aging, Context, Diet, Environments, Physiology, Population | Tagged , ,

Welcome to Michael Rose’s 55 Theses – A New Context for Health

Introduction Welcome to Michael Rose’s 55, an overarching context that will enable you to use nature’s rules to make sense of your health and take action to make your life much better. You will do this by changing how you … Continue reading

Posted in Context | Tagged , , , | 3 Comments

The Scientific Challenge

Biology is in a state of transformation.  Much like the re-foundings of biology that took place after 1800, 1859, 1900 and 1952, the first decade of the 21st Century has seen a major upheaval in biology.  The four previous revolutionary episodes … Continue reading

Posted in A New Vision, Context

Thesis 24

Thesis #24 – Altering all cell-molecular regulatory signaling during the aging phase will provide at most partial amelioration for the problem of declining adaptation, because dysfunctional signaling will also arise at organ and systemic levels as a result of the … Continue reading

Posted in Complexity, Context, Forces of Natural Selection, Theses, Tuning | Tagged ,

Thesis 25

Thesis #25 – Repairing all forms of cumulative damage and altering all types of regulatory signaling during the aging phase will also fail to fully alleviate aging, because some features of aging will arise from the absence of structural gene-products … Continue reading

Posted in Complexity, Constraints, Context, Physiology, Theses | Tagged , | 2 Comments

Thesis 28

Thesis #28 – Among such experimental populations evolving greater levels of adaptation at later adult ages, evolutionary changes in (a) structural gene frequency, (b) gene regulation, (c) patterns of cumulative damage, and (d) still other features of physiological function will … Continue reading

Posted in A New Vision, Aging, Context, Forces of Natural Selection, The New Science, Theses | Tagged ,

Thesis 31

Thesis #31 – After the forces of natural selection plateau, it is possible for survival and reproduction to plateau at positive values due to age-independent beneficial effects of some genetic variants. As with modern physics, again, it is often difficult … Continue reading

Posted in A New Vision, Aging, Complexity, Context, Forces of Natural Selection, The New Science, The Plateau, Tuning | Tagged , , , | 1 Comment

Thesis 38

Thesis #38 – Some environmentally-induced variation in patterns of aging reflects the impact of selectively-favored patterns of life-history plasticity, but some environmental variation in aging does not reflect adaptive plasticity, such as that due to novel environments. An important distinction … Continue reading

Posted in Aging, Complexity, Context, Environments, Physiology, The New Science, The Science, Theses | Tagged ,

Thesis 40

Thesis #40 – Experimental strategies for the study of aging that involve the introduction of novel mutations or increased levels of inbreeding will systematically impair the scientific study of aging, as they degrade and disrupt adaptation generally. At this point, … Continue reading

Posted in A New Vision, Aging, Constraints, Context, Forces of Natural Selection, The Science, Theses | Tagged ,

Thesis 41

Thesis #41 – Experimental strategies for the study of aging that involve the use of environments that are evolutionarily novel will systematically impair the scientific study of aging, as natural selection will not have previously fostered adaptation to such novel … Continue reading

Posted in A New Vision, Aging, Complexity, Constraints, Context, Environments, Evolutionary Novelty, Forces of Natural Selection, Physiology, The New Science, The Science, Theses | Tagged , ,

Thesis 42

Thesis #42 – As a pattern of age-dependent adaptation, aging and the post-aging period are best studied using the range of methods used to study adaptation by evolutionary biologists, such as the comparative method, experimental evolution, and genomics. By this … Continue reading

Posted in A New Vision, Aging, Context, Forces of Natural Selection, The New Science, The Science, Theses | Tagged , , , , ,

Thesis 43

Thesis #43 – Experimental manipulation of the forces of natural selection is one of the most powerful methods of studying the biological foundations of aging, because it can direct experimental evolution to produce extensive genetic differentiation with respect to both … Continue reading

Posted in A New Vision, Aging, Context, Experimental Evolution, Forces of Natural Selection | Tagged , ,

Thesis 44

Thesis #44 – Most of our ancestral hominin populations of the last million years benefited from increased forces of natural selection at early adult ages under conditions of relatively abundant nutrition derived from hunting, gathering, and cooking and an increased … Continue reading

Posted in A New Vision, Context, Environments, Forces of Natural Selection, Population, The New Science, The Science, Theses | Tagged ,

Thesis 45

Thesis #45 – Our ancestral hunter-gatherer populations had generally low population densities, and thus low effective population sizes, which produced relatively early cessation of aging at relatively high function due to genetic drift. With very low population densities among our … Continue reading

Posted in A New Vision, Aging, Context, Environments, Forces of Natural Selection, Population, Reproduction, The New Science, The Plateau, The Science, Theses, Trade Offs, Tuning | Tagged , , ,

Thesis 46

Thesis #46 – In the last ten to twenty thousand years, some human populations adopted extensive agricultural cultivation of grass species and the use of milk from other mammals for nutrition, a novel environment which changed the action of natural … Continue reading

Posted in A New Vision, Aging, Context, Environments, Evolutionary Novelty, Forces of Natural Selection, Population, The New Science, The Plateau, The Science, Theses | Tagged ,

Thesis 47

Thesis #47 – This novel agricultural lifestyle initially depressed adaptation and health, leading to intense natural selection for adaptations to the digestion of foods derived from grasses and milk, which has since produced adaptation to agricultural conditions at early ages. … Continue reading

Posted in A New Vision, Aging, Complexity, Constraints, Context, Environments, Forces of Natural Selection, Physiology, The New Science, The Science, Theses | Tagged , , , | 2 Comments

Thesis 49

Thesis #49 – In agricultural populations over the last ten thousand years, the longer-sustained effectiveness of natural selection has resulted in an age-dependent pattern of falling adaptation to agricultural conditions in which functional decline is sustained over a longer period … Continue reading

Posted in A New Vision, Aging, Context, Environments, Forces of Natural Selection, Physiology, Population, The New Science, The Plateau, The Science, Theses, Tuning | Tagged , , , , ,

Thesis 50

Thesis #50 – Children and young adults with predominantly agricultural ancestry are well adapted to agricultural conditions of nutrition and activity, but children and young adults without agricultural ancestry are not adapted to such conditions. Let us address with particular … Continue reading

Posted in A New Vision, Aging, Ancestry, Context, Diet, Environments, Forces of Natural Selection, Physiology, Population, The New Science, The Plateau, The Science, Theses | Tagged , | 2 Comments

Thesis 51

Thesis #51 – Older adults from all human populations are not adequately adapted to agricultural patterns of nutrition and activity, resulting in an amplification of aging under such conditions. Naturally, older adults from non-agricultural populations will be no better adapted … Continue reading

Posted in A New Vision, Aging, Ancestry, Context, Diet, Environments, Forces of Natural Selection, Physiology, Population, The New Science, The Plateau, The Science, Theses | Tagged , | 3 Comments

Thesis 52

Thesis #52 – All people without significant agricultural ancestry should revert to patterns of nutrition and activity which have physiological effects like those of hunter-gatherer lifestyles, in order to slow their aging and hasten its cessation. The case of individuals … Continue reading

Posted in A New Vision, Aging, Ancestry, Context, Diet, Environments, Forces of Natural Selection, Physiology, Population, The New Science, The Plateau, The Science, Theses, Tuning | Tagged , , | 3 Comments

Thesis 53

Thesis #53 – Young people with significant agricultural ancestry can sustain their health with agricultural patterns of nutrition and activity, but not with an evolutionarily novel industrial lifestyle. It is tempting to suppose that young people with agricultural ancestry are … Continue reading

Posted in A New Vision, Aging, Ancestry, Constraints, Context, Diet, Environments, Evolutionary Novelty, Forces of Natural Selection, Physiology, Population, The New Science, The Plateau, The Science, Theses | Tagged , | 1 Comment

Thesis 54

Thesis #54 – Older adults with significant agricultural ancestry cannot sustain their health with either agricultural or industrial patterns of nutrition and activity, and should instead switch to hunter-gatherer patterns of nutrition and activity in order to slow their later … Continue reading

Posted in "Paleo", A New Vision, Aging, Ancestry, Context, Diet, Environments, Evolutionary Novelty, Forces of Natural Selection, Physiology, The New Science, The Plateau, The Science, Theses, Trade Offs, Tuning | 1 Comment

Thesis 55

Thesis #55 – Once this switch to a hunter-gatherer lifestyle among older adults has become widespread, further changes that would enhance human health at later ages can be discovered using evolutionary research tools, such as experimental evolution with model organisms … Continue reading

Posted in "Paleo", A New Vision, Aging, Context, Diet, Environments, Evolutionary Novelty, Forces of Natural Selection, The New Science, The Plateau, The Science, Theses | Tagged , | 3 Comments